What are the terminally differentiated keratinocytes that constitute the majority of the outer layer of human skin called?

Prepare for the Mandalyn Academy Master State Board Test with Qandamp;A flashcards and comprehensive explanations. Ace your written exam!

The terminally differentiated keratinocytes that form the majority of the outer layer of human skin are known as corneocytes. These cells are essential for the skin's barrier function, as they are part of the stratum corneum, the outermost layer of the epidermis. Corneocytes are characterized by their flattened shapes and the presence of keratin, a fibrous protein that provides strength and resilience to the skin.

As corneocytes lose their nuclei and other organelles during their maturation process, they contribute to the protective barrier that prevents water loss and protects against environmental hazards. This differentiation process is critical for maintaining skin health and integrity, making corneocytes a key component of the skin’s structure and functionality.

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