Which epidermal layer is characterized by granules and a disappearing nucleus?

The epidermal layer characterized by granules and a disappearing nucleus is the Stratum Granulosum. This layer is situated above the Stratum Spinosum and plays a critical role in the process of keratinization, where cells begin to die and accumulate keratin.

In this layer, keratinocytes contain keratohyalin granules, which help to bind keratin filaments together and contribute to the waterproof barrier of the skin. The granules in the Stratum Granulosum are essential for creating the protective outer layer of the skin, as they produce lipids that fill the spaces between cells, preventing water loss and providing an essential barrier function.

As the cells transition through this layer, they move towards the Stratum Lucidum or Stratum Corneum, where they ultimately lose their nuclei and become fully keratinized, thus ensuring that the outermost layer of skin remains both resilient and impervious to external elements.